Cyclosporin A therapy in a case with hyperimmunoglobulin E and nephritic syndrome

Chin-Nam Bong¹, Shun-Chen Huang², Chih-Lu Wang³, Po-Mai Liu³, Hsin-Hsu Chen³, Kuender D. Yang^3
1Department of Pediatrics, Pingtung Christian Hospital, Pingtung; and Departments of ²Pathology and ³Pediatrics, Chang Gung Children's Hospital, Kaohsiung, Taiwan

Received: January 19, 2004 Revised: April 24, 2004 Accepted: May 24, 2004

Corresponding author: Dr. Kuender D. Yang, Department of Pediatrics, Chang Gung Children's Hospital, 123, Ta-Pei Road, Niaosung Hsiang, Kaohsiung 833, Taiwan. E-mail:

We describe the beneficial effects of treatment with cyclosporin A in a 10-year-old boy with hyperimmunoglobulin E and refractory nephrotic syndrome. The patient was initially resistant to steroid therapy with prednisolone alone. Additional therapy with cyclosporin A was then prescribed, effectively reducing levels of serum immunoglobulin E and preventing flare up of nephrotic syndrome.

Key words: Cyclosporin A, hyperimmunoglobulin E syndrome, nephrotic syndrome, prednisolone

J Microbiol Immunol Infect 2005;38:60-64.