Antitumor features of Bacillus oligonitrophilus KU-1 strain

Sergey V. Malkov¹ Vladimir V. Markelov², Gleb Y. Polozov¹, Larisa I. Sobchuk¹,Natalia G. Zakharova¹,Boris I. Barabanschikov¹, Alexander Y. Kozhevnikov³,Rauf A. Vaphin¹, Maxim V. Trushin^1,3
1Department of Genetics, Kazan State University, Kazan; ²Kazan Municipal Rehabilitation
Medical Health Center "Sanatorium Krutushka", Kazan; and ³Kazan Institute of Biochemistry and Biophysics, Kazan, Russia

Received: August 20, 2004 Revised: November 10, 2004 Accepted: November 26, 2004

Corresponding author: Maxim V. Trushin, Department of Genetics, Kazan State University, Kremlyovskaya Street 18, Kazan 420008, Russia. E-mail:

Chemotherapy and radiotherapy remain mostly palliative methods for metastatic cancer treatment. Limitations in efficacy and safety of established treatments continue to underline the need for improved treatments for malignancy. Results with some probiotics with antitumor activity have been promising. Here, we report that oral reception of Bacillus oligonitrophilus KU-1 resulted in the prolongation of lives in cancer patients with terminal prognosis and stabilization of cancer growth. The theoretical basis for the phenomena observed is discussed.

Key words: Bacillus subtilis, genome, neoplasm metastases, probiotics

J Microbiol Immunol Infect 2005;38:96-104.